I've used some really good coils, many peoples favorites, and after burning up a spot with one of them I can switch coils and go over the same area and find some stuff that was missed by the previous coils. They all have their pros and cons and specialty designs. For really high mineralization the 5.3 will work well. I've heard the SEF coils are designed for high mineralization but I havn't used them. I use the D2 coil a lot and it does really well in high mineralization because it sees very little ground at any given time(long narrow but deep signal). Generally speaking, the less ground the coil sees the better it will handle mineralization since it deals with less of it at once. Small coils and DD coils are good, SEF coils have a similar design to DD coils in that the TX & RF windings are side by side and create an overlapping signal in a narrow elongated shape.
The same principle applies to really large coils, especially large concentric coils. Because they are 'looking at' so much ground at once, there is a LOT of mineralization to see through which is like looking through extremely dense fog with high beams. Bigger is only better in a few places, you have to pick your coil to match the ground and sought after targets.